Markan and LabCat will be at SupplySide West - October 19-23 Booth #11015
Evonik Degussa Corp. introduces the first compendial grade hydrophobic colloidal
JRS Pharma’s "PROSOLV® EASYtab" - exciting All-in-One, High Functionality, Excipient Composite
JRS Pharma to introduce its newest product derived from PROSOLV® Technology
Aerosil 200 Pharma is a high purity amorphous anhydrous colloidal silicon dioxide for use in pharmaceutical products. Aerosil 200 Pharma is the traditional choice for glidant applications and also the best choice for viscosity control.
(Tested according to USP/NF, Ph. Eur. and JP).
Aerosil R 972 Pharma is a colloidal silicon dioxide that has been chemically treated to render its surface hydrophobic. Aerosil R 972 Pharma is an excellent glidant for improving the powder flow of hygroscopic and/or cohesive powders.
(Tested according to USP/NF, Ph. Eur.)
Sipernat 22S is used extensively as a flow and anticaking agent in many applications. It is a fine particle silica with high absorption capacity for liquids.
Sipernat 50 is an excellent carrier silica for converting liquid substances into free flowing powders. Concentrates of up to 75% can be produced by using Sipernat 50. Also good as an anticaking and free flow aid.
Sipernat 50S enhances flowability and prolongs the shelf life of powdered substances (especially powders prone to caking). It is a fine particle silica with high absorption capacity for liquids.
Powdered Cellulose, Ph. Eur., NF, JP
Powdered cellulose is used as an economic and inert diluent in tableting and capsule filling. Especially in wet granulation it works synergistically with other economic excipients such as starch or lactose. Combined with these, ARBOCEL® improves tablet hardness and disintegration time.
Grade | Average Particle Size by Laser Diffraction (µm) |
Bulk Density (typical) (g/cm 3) | Main Application |
---|---|---|---|
ARBOCEL® M80 | 60 | 0.22 | Fine, fibrous grade of powdered cellulose, suitable for wet granulation. |
ARBOCEL® P290 | 80 | 0.30 | Fine grade with increased density and improved flow. Suitable for wet granulation and direct compression, especially in combination with MCC. |
ARBOCEL® A300 | 250 | 0.35 | Coarse grade with excellent flow properties used in direct compression and for capsule fillings. |
Candex is a soluble tablet binder that is composed mainly of dextrose with small amounts of starch oligosaccharides.
Calcium Sulfate Dihydrate, Ph. Eur., USP/NF
COMPACTROL® is a specially processed Calcium Sulfate Dihydrate for use as a filler in tablets made by direct compression or a binder in wet granulation.
Grade | Bulk Density | Median Particle Size |
---|---|---|
COMPACTROL® |
< 0.75 - 1.10 g/mL | 120 µm |
Calcium Hydrogen Phosphate Dihydrate, Ph. Eur. Dibasic Calcium Phosphate, USP, Dihydrate
Calcium Hydrogen Phosphate Dihydrate / Dibasic Calcium Phosphate is a superior inorganic binder. It has a unique particle size, shape and density to maximize flow in high speed tablet production.
Grade | Chemical Structure | Main Application |
---|---|---|
EMCOMPRESS® | CaHPO4 • 2 H2O | Monoclinic crystal. Standard grade with excellent flow properties. |
ANHYDROUS EMCOMPRESS¨ |
CaHPO4 | Triclinic crystal. Special grade, offers improved compressibility and moisture stability in tableting. Ideal flow enhancer for capsule fillings. |
Microcrystalline Cellulose, Ph. Eur., NF, JP
Grade | Average Particle Size by Laser Diffraction (µm) | Bulk
Density (g/cm 3) |
Main Application |
---|---|---|---|
EMCOCEL® SP15 | 15 | > 0.13 | For use as a suspension aid and an auxiliary disintegrant. |
EMCOCEL® 50M | 65 | 0.25 - 0.37 | Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility. |
EMCOCEL® LM50 | 65 | 0.25 - 0.37 | Equal quality as grade 101/50M, but very low moisture content (< 1.5% resp. 3%) for processing water-sensitive actives. |
EMCOCEL® 90M | 100 | 0.25 - 0.37 | Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility. |
EMCOCEL® XLM90 | 100 | 0.25 - 0.37 | Equal quality to grades 102/90M, but very low moisture content (< 1.5%) for processing water-sensitive actives. |
EMCOCEL® HD90 | 100 | 0.35 - 0.50 | Equal quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives. |
EMCOCEL¨ LP200 | 190 | 0.25 - 0.37 | Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation Ð even when used with low concentrations of fine actives. |
Dextrates, NF
Ideal for chewable and soluble tablets, EMDEX® is the only compendial (NF) dextrate that delivers the required flow, compaction, taste masking and flavor carrying capacity. It is highly water-soluble and gives a cool smooth mouth feel.
EMDEX® is also available GMO free.
Sodium Starch Glycolate, Ph. Eur., NF
Grade | pH Value | Main Application |
---|---|---|
EXPLOTAB® |
5.5 - 7.5 | Superdisintegrant with a rapid and high degree of swelling for capsule formulations. Especially for poor water soluble actives and tablet matrices with higher pH values. |
EXPLOTAB® CLV | 5.5 - 7.5 | Special grade with increased number of crosslinkings. Especially suited for wet granulation applications. |
Soy Polysaccharides
An all natural superdisintegrant, which does not contain starch or sugar.
Being a dietary fiber, it has excellent application in nutritional products.
Hydrogenated Vegetable Oil, NF, BP
Hydrogenated Oil, JP
LUBRITAB® is made from hydrogenated cottonseed oil. As a plant-derived product it is the ideal lubricant for health supplement and neutraceutical products. It can also be used as a binder and controlled release matrix. The lubrication effect of LUBRITAB® occurs mainly at the outer parts of the tablet, which helps to overcome specific sticking and picking problems.
Silicified Microcrystalline Cellulose (Microcrystalline Cellulose, Ph. Eur., NF, JP & Silica, Colloidal Anhydrous, Ph. Eur. & Colloidal Silicon Dioxide NF & Light Anhydrous Silicic Acid JP)
High functionality excipients are inactive ingredients that meet four criteria:
A portfolio of high functionality excipients that imparts superior flow, compaction and dispersion to a formulation. When used in direct compression, PROSOLV SMCC® can replace granulations, while significantly reducing excipient numbers and levels. PROSOLV SMCC® formulations produce distinctive, uniform, cost effective tablets.
Grade | Average Particle Size by Laser Diffraction (µm) | Bulk Density (g/cm 3) |
Main Application |
---|---|---|---|
PROSOLV SMCC® 50 | 60 | 0.25 - 0.37 | Formulas where optimal compaction is required. |
PROSOLV SMCC® 90 | 110 | 0.25 - 0.37 | Formulas where a balance of flow and compaction is required.*low moisture grade avaliable on request |
PROSOLV SMCC® HD90 |
110 | 0.35 - 0.50 | Formulas where optimal flow and consolidation is required. *low moisture grade avaliable on request |
Sodium Stearyl Fumarate,
Ph. Eur., NF, JPE
PRUV® is a hydrophilic lubricant. It avoids many problems associated with magnesium stearate including active incompatibility*, over lubrication, and film formation in effervescent tablets. Product development time and bioavailability of certain actives can be improved.
* e.g. Azathioprin, Cefaclor, Cilazapril, Clarithromycin, Clopidogrelacetate, Diclofenac, Fosinopril, Ibuprofen, Ketorolac, Levofloxacin, Nifedipin, Omeprazol, Ramipril, Trandolapril.
Microcrystalline Cellulose, Ph. Eur., NF, JP
Grade | Average Particle Size by Laser Diffraction (µm) | Bulk
Density (g/cm 3) |
Main Application |
---|---|---|---|
VIVAPUR® 101 | 65 | 0.26 - 0.31 | Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility. |
VIVAPUR® 102 | 100 | 0.28 - 0.33 | Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility. |
The Innovative MCC- Grade for Direct Compression | |||
VIVAPUR® 12 | 180 | 0.30 - 0.36 | Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation & even when used with low oncentrations of fine actives. |
VIVAPUR® 200 | 250 | 0.31 - 0.37 | Large size MCC grade with excellent flow properties for a variety of direct compression formulations. |
Croscarmellose Sodium, Ph. Eur., NF, JP
VIVASOL® is a cellulose-based superdisintegrant, providing excellent results in tablet disintegration and dissolution.
Used at a level of 1 - 2% only, it is one of the most efficient superdisintegrants in the pharmaceutical market.
VIVASOL® can be used in all tableting processes. Especially good for medium soluble actives.
Sodium Carboxymethyl Starch, JPE
Grade | pH Value | Main Application |
---|---|---|
VIVASTAR® P | 5.5 - 7.5 | Superdisintegrant with a rapid and high degree of swelling for capsule formulations. Especially for poor water soluble actives and tablet matrices with lower pH values. |
VIVASTAR® PSF | 5.5 - 7.5 | Special grade with very low methanol content. Especially suited for alcohol and moisture sensitive actives. |
VIVASTAR® Low PH | 3.0 - 5.0 | Special grade with low pH value. Complies with Typ (B) Ph. Eur, NF. |